global dissemination of the mcr-1 gene
نویسندگان
چکیده
antimicrobial resistance is one of the most severe threats to human health. the first report of plasmid-mediated colistin resistance in escherichia coli from animals, food, and humans was in 2015 from china. the current increasing trend of resistance is extremely troubling because polymyxins are the last-resort antibiotics for treating infections with carbapenem-resistant enterobacteriaceae.
منابع مشابه
Dissemination and Mechanism for the MCR-1 Colistin Resistance
Polymyxins are the last line of defense against lethal infections caused by multidrug resistant Gram-negative pathogens. Very recently, the use of polymyxins has been greatly challenged by the emergence of the plasmid-borne mobile colistin resistance gene (mcr-1). However, the mechanistic aspects of the MCR-1 colistin resistance are still poorly understood. Here we report the comparative genomi...
متن کاملSilent dissemination of colistin-resistant Escherichia coli in South America could contribute to the global spread of the mcr-1 gene.
During a Brazilian multicentric antimicrobial resistance surveillance study, colistin resistance was investigated in 4,620 Enterobacteriaceae isolated from human, animal, food and environmental samples collected from 2000 to 2016. We present evidence that mcr-1-positive Escherichia coli has been emerging in South America since at least 2012, supporting a previous report on the possible acquisit...
متن کاملComplex dissemination of the diversified mcr-1-harbouring plasmids in Escherichia coli of different sequence types
The emergence of the mobilized colistin resistance gene, representing a novel mechanism for bacterial drug resistance, challenges the last resort against the severe infections by Gram-negative bacteria with multi-drug resistances. Very recently, we showed the diversity in the mcr-1-carrying plasmid reservoirs from the gut microbiota. Here, we reported that a similar but more complex scenario is...
متن کاملMultiplex PCR for detection of plasmid-mediated colistin resistance determinants, mcr-1, mcr-2, mcr-3, mcr-4 and mcr-5 for surveillance purposes
Background and aimPlasmid-mediated colistin resistance mechanisms have been identified worldwide in the past years. A multiplex polymerase chain reaction (PCR) protocol for detection of all currently known transferable colistin resistance genes (mcr-1 to mcr-5, and variants) in Enterobacteriaceae was developed for surveillance or research purposes. Methods: We designed four new primer pairs to ...
متن کاملthe relationship between field-related cognitive styles and global reading comprehension of hypertext
this study investigates the relationship between field-related cognitive styles and global reading comprehension of hypertext. technically, field dependency is prevailing dominance of field on perception of parts, while global comprehension is skim-like reading to grasp the general content. in this research project, 60 senior and junior students of arak university majoring in english literature...
15 صفحه اولThe Occurrence of the Colistin Resistance Gene mcr-1 in the Haihe River (China)
Antibiotic failure is occurring worldwide. In a routine surveillance study on antibioticresistance genes (ARGs) in natural water bodies, we noted the detection of colistin-resistance gene mcr-1, previously identified in Escherichia coli and Klebsiella pneumoniae isolates from human beings and animals in several countries. The mcr-1 gene might be present in water environments, because aquatic ec...
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عنوان ژورنال:
archives of pediatric infectious diseasesجلد ۴، شماره ۳، صفحات ۰-۰
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